Microfluidic impedance-based diagnostic sensors for blood disorders


 
Objective: To develop portable, low-cost microfluidic platforms capable of diagnosing blood diseases from minimal blood volumes, using impedance spectroscopy for rapid, real-time assessment.
Overview: Our research aims to create next-generation diagnostic devices that harness microfluidic channels and impedance-based sensing for analyzing blood composition and identifying diseases such as sepsis, anemia, coagulation disorders, and zoonotic infections. These devices are designed for point-of-care settings, with the goal of shifting diagnostics from centralized labs to on-site and accessible platforms in veterinary and clinical environments. By leveraging impedance spectroscopy, our sensors provide high-sensitivity detection with minimal blood volume, making them ideal for both human and animal health applications.
Applications: Blood disease diagnostics, veterinary diagnostics, on-site testing for zoonotic diseases, and early infection monitoring in healthcare and agriculture. 

Publications


Monitoring DOACs with a novel dielectric microsensor: a clinical study


Debnath Maji, Aman Opneja, Michael A Suster, Kara L Bane, Brigid M Wilson, Pedram Mohseni, Evi X Stavrou

Thrombosis and haemostasis, vol. 121, Georg Thieme Verlag KG, 2021, pp. 058--069


Microfluidic electrical impedance assessment of red blood cell-mediated microvascular occlusion


Yuncheng Man, Debnath Maji, Ran An, Sanjay P Ahuja, Jane A Little, Michael A Suster, Pedram Mohseni, Umut A Gurkan

Lab on a Chip, vol. 21, Royal Society of Chemistry, 2021, pp. 1036--1048


Assessment of whole blood coagulation with a microfluidic dielectric sensor


Debnath Maji, Maria De La Fuente, Erdem Kucukal, Ujjal DS Sekhon, Alvin H Schmaier, A Sen Gupta, Umut A Gurkan, Marvin T Nieman, Evi X Stavrou, Pedram Mohseni, others

Journal of Thrombosis and Haemostasis, vol. 16, Elsevier, 2018, pp. 2050--2056